The protective effect of goji berry extract in ischemic reperfusion in testis torsion
Recep Dursun1 , Yılmaz Zengin1 , Ercan Gündüz1 , Mustafa İçer1 , Hasan Mansur Durgun1 , Mansur Dağgulli2 , İbrahim Kaplan3 , Ulaş Alabalık4 , Cahfer Güloğlu1 Departments of 1Emergency Medicine, 2Urology, 3Biochemistry, 4Pathology, Medical Faculty, Dicle University, Diyarbakır, Turkey Received October 14, 2014; Accepted January 21, 2015; Epub February 15, 2015; Published February 28, 2015
Abstract: This study investigated whether goji berry extract (GBE), a known antioxidant, reduces ischemic reperfusion injury when administered to rats exposed to experimental testis torsion. A total of 32 Sprague-Dawley male rats were randomized into 4 groups, including the control (sham), goji, torsion, and torsion-goji groups. The treatment groups received intraperitoneal GBE prior to torsion. The left testes of the animals were subjected to torsion via 5 hours of ischemia and 6 hours of reperfusion. TAC (total antioxidant capacity), TOS (total oxidant status) and OSI (oxidative stress index) levels were calculated. Approximately 5-μm-thick sections were stained with hematoxylineosin (H&E) and examined under a light microscope. Statistical analyses were performed with the SPSS 15 software package. The mean serum TAC level was significantly increased in Groups 2 and 4 compared with Groups 1 and 3 in biochemical analyses (for both P < 0.001). The mean serum TOS level was significantly increased in Group 3 compared with Groups 1, 2, and 4 (P < 0.001, P < 0.001, and P = 0.003, respectively). Comparison of the groups with regard to histopathological examination revealed that Group 4 exhibited a significantly higher rate of hemorrhage and congestion compared with Groups 1 and 2 (P = 0.038). The groups did not differ significantly with respect to degeneration. Ischemic reperfusion injury associated with testis torsion was reduced by the antioxidant effect of GBE. Further experimental and clinical studies are needed to confirm the agent’s efficacy for this indication.
Keywords: Antioxidant, lycium, goji berry extract, testis torsion
*This is a literature on the study of goji berry and antioxidants . You can click here to read the full text.
